Publications: Lusutrombopag

  • Effects of food and calcium carbonate on the pharmacokinetics of lusutrombopag, a novel thrombopoietin receptor agonist

    Clinical Therapeutics.

    Katsube T<sup>1</sup>, Wajima T<sup>1</sup>, Fukuhara T<sup>2</sup>, Kano T<sup>3</sup>.

    <sup>1</sup>Clinical Pharmacology & Pharmacokinetics, Shionogi & Co, Ltd, Osaka, Japan; <sup>2</sup>Clinical Research Department, Shionogi & Co, Ltd, Osaka, Japan; <sup>3</sup>Project Management Department, Shionogi & Co, Ltd, Osaka, Japan.

  • Safety and effectiveness of lusutrombopag in Japanese chronic liver disease patients with thrombocytopenia undergoing invasive procedures: Interim results of a postmarketing surveillance

    Hepatology Research.

    Sasaki R<sup>1</sup>, Shiino C<sup>2</sup>, Imawari M<sup>3</sup>, Bentley R<sup>4</sup>, Cai B<sup>5</sup>, Yoshida M<sup>6</sup>, Afdhal N<sup>7</sup>.

    <sup>1</sup>Pharmacovigilance Department, Shionogi; <sup>2</sup>Postmarketing Surveillance & Pharmacoepidemiology Department, Shionogi Pharmacovigilance Center, and <sup>6</sup>Medical Affairs, Shionogi, Osaka; <sup>3</sup>Institute for Gastrointestinal and Liver Diseases, Shin-Yurigaoka General Hospital, Kawasaki, Japan; <sup>4</sup>Global Market Access, Shionogi; <sup>5</sup>Global Observational Research, Epidemiology and Health Outcomes, Shionogi, Florham Park, New Jersey; <sup>7</sup>Liver Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

  • Pharmacokinetic/Pharmacodynamic Modelling and Simulation of Lusutrombopag, a Novel Thrombopoietin Receptor Agonist, for the Treatment of Thrombocytopenia in Patients with Chronic Liver Disease Undergoing Invasive Procedures

    Clinical Pharmacokinetics.

    Katsube T<sup>1</sup>, Shimizu R<sup>1</sup>, Fukuhara T<sup>2</sup>, Kano T<sup>3</sup>, Wajima T<sup>1</sup>.

    <sup>1</sup>Clinical Pharmacology and Pharmacokinetics, Shionogi & Co., Ltd, Osaka, Japan; <sup>2</sup>Clinical Research Department, Shionogi & Co., Ltd, Osaka, Japan; <sup>3</sup>Project Management Department, Shionogi & Co., Ltd, Osaka, Japan.

  • Lusutrombopag for the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Invasive Procedures (L-PLUS 2)

    Hepatology.

    Peck-Radosavljevic M<sup>1</sup>, Simon K<sup>2</sup>, Iacobellis A<sup>3</sup>, Hassanein T<sup>4</sup>, Kayali Z<sup>5</sup>, Tran A<sup>6,7</sup>, Makara M<sup>8</sup>, Ben Ari Z<sup>9</sup>, Braun M<sup>10</sup>, Mitrut P<sup>11</sup>, Yang SS<sup>12</sup>, Akdogan M<sup>13</sup>, Pirisi M<sup>14</sup>, Duggal A<sup>15</sup>, Ochiai T<sup>16</sup>, Motomiya T<sup>16</sup>, Kano T<sup>16</sup>, Nagata T<sup>16</sup>, Afdhal N<sup>17</sup>.

    <sup>1</sup>Abteilung Innere Medizin & Gastroenterologie, mit Zentraler Aufnahme & Erstversorgung, Klinikum Klagenfurt am Wörthersee, Klagenfurt, Austria; <sup>2</sup>Department of Infectious Diseases and Hepatology, Wroclaw Medical University, Wroclaw, Poland; <sup>3</sup>Division of Gastroenterology, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; <sup>4</sup>Southern California Research Center, Coronado, CA; <sup>5</sup>Inland Empire Liver Foundation, University of California, Riverside, Rialto, CA; <sup>6</sup>Institut national de la santé et la recherche médicale (INSERM), Unit 1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Team 8: “Chronic liver diseases associated with obesity and alcohol,” Nice, France; <sup>7</sup>Centre Hospitalier Universitaire de Nice, Digestive Center, Nice, France; <sup>8</sup>Dél-pesti Centrumkórház–Országos Hematológiai és Infektológiai Intézet, Budapest, Hungary; <sup>9</sup>Liver Disease Center, Chaim Sheba Medical Center, Ramat Gan, Israel; <sup>10</sup>Department of Gastroenterology, Rabin Medical Center Belinson Campus, Petah-Tikva, Israel; <sup>11</sup>Spitalul Clinic Judetean de Urgenta Craiova, Craiova, Romania; <sup>12</sup>Division of Gastroenterology & Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; <sup>13</sup>Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey; <sup>14</sup>Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy; <sup>15</sup>Shionogi Ltd., Holborn, London, United Kingdom; <sup>16</sup>Shionogi & Co., Ltd., Osaka, Japan; <sup>17</sup>Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

  • Lusutrombopag Reduces Need for Platelet Transfusion in Patients With Thrombocytopenia Undergoing Invasive Procedures

    Clinical Gastroenterology and Hepatology.

    Hidaka H<sup>1</sup>, Kurosaki M<sup>2</sup>, Tanaka H<sup>3</sup>, Kudo M<sup>4</sup>, Abiru S<sup>5</sup>, Igura T<sup>6</sup>, Ishikawa T<sup>7</sup>, Seike M<sup>8</sup>, Katsube T<sup>9</sup>, Ochiai T<sup>9</sup>, Kimura K<sup>9</sup>, Fukuhara T<sup>9</sup>, Kano T<sup>9</sup>, Nagata T<sup>9</sup>, Tanaka K<sup>10</sup>, Kurokawa M<sup>11</sup>, Yamamoto K<sup>12</sup>, Osaki Y<sup>13</sup>, Izumi N<sup>2</sup>, Imawari M<sup>14</sup>.

    <sup>1</sup>Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan; <sup>2</sup>Department of Gastroenterology and Hepatology, Japanese Red Cross Society Musashino Hospital, Musashino, Japan; <sup>3</sup>Internal Medicine, Hyogo College of Medicine Hospital, Nishinomiya, Japan; <sup>4</sup>Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osakasayama, Japan; <sup>5</sup>Department of Hepatology, National Hospital Organization Nagasaki Medical Center, Omura, Japan; <sup>6</sup>Department of Gastroenterology, Ikeda Municipal Hospital, Ikeda, Japan; <sup>7</sup>Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan; <sup>8</sup>Department of Gastroenterology, Oita University Hospital, Yufu, Japan; <sup>9</sup>Shionogi & Co, Ltd, Osaka, Japan; <sup>10</sup>Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan; <sup>11</sup>Department of Hematology and Oncology, The University of Tokyo Hospital, Tokyo, Japan; <sup>12</sup>Department of Internal Medicine, Okayama University Hospital, Okayama, Japan; <sup>13</sup>Japanese Red Cross Society Osaka Hospital, Osaka, Japan;  <sup>14</sup>Institute for Gastrointestinal and Liver Diseases, Shin-yurigaoka General Hospital, Kawasaki, Japan.

  • A randomized controlled trial of lusutrombopag in Japanese patients with chronic liver disease undergoing radiofrequency ablation

    Journal of Gastroenterology.

    Tateishi R<sup>1</sup>, Seike M<sup>2</sup>, Kudo M<sup>3</sup>, Tamai H<sup>4,13</sup>, Kawazoe S<sup>5,14</sup>, Katsube T<sup>6</sup>, Ochiai T<sup>6</sup>, Fukuhara T<sup>6</sup>, Kano T<sup>6</sup>, Tanaka K<sup>7,15</sup>, Kurokawa M<sup>8</sup>, Yamamoto K<sup>9,16</sup>, Osaki Y<sup>10,17</sup>, Izumi N<sup>11</sup>, Imawari M<sup>12</sup>.

    <sup>1</sup>Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan; <sup>2</sup>Department of Gastroenterology, Oita University Hospital, Yufu, Japan; <sup>3</sup>Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-sayama, Japan; <sup>4</sup>Second Department of Internal Medicine, Wakayama Medical University Hospital, Wakayama, Japan; <sup>5</sup>Department of Hepatobiliary and Pancreatology, Saga-ken Medical Centre Koseikan, Saga, Japan; <sup>6</sup>Shionogi and Co., Ltd.Osaka, Japan; <sup>7</sup>Yokohama City University Medical Center, Gastroenterological Center, Yokohama, Japan; <sup>8</sup>Department of Hematology and Oncology, The University of Tokyo Hospital, Tokyo, Japan; <sup>9</sup>Gastroenterology and Hepatology Department, Okayama University Hospital, Okayama, Japan; <sup>10</sup>Department of Gastroenterology and Hepatology, Japanese Red Cross Society Osaka Hospital, Osaka, Japan; <sup>11</sup>Japanese Red Cross Society Musashino Hospital, Tokyo, Japan; <sup>12</sup>Institute for Gastrointestinal and Liver Diseases, Shin-yurigaoka General Hospital, Kawasaki, Japan; <sup>13</sup>Department of Hepatology, Wakayama Rousai Hospital, Wakayama, Japan; <sup>14</sup>Kawazoe Medical Clinic, Saga, Japan; <sup>15</sup>Japanese Red Cross Society Hadano Hospital, Hadano, Japan; <sup>16</sup>Okayama Saiseikai General Hospital, Okayama, Japan; <sup>17</sup>Meiwa Hospital, Nishinomiya, Japan.